umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Persistence of immunity in healthy adults aged >= 50 years primed with a hepatitis B vaccine 3 years previously
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Infectious Diseases.
Show others and affiliations
2015 (English)In: Human Vaccines & Immunotherapeutics, ISSN 2164-5515, E-ISSN 2164-554X, Vol. 11, no 7, 1709-1716 p.Article in journal (Refereed) Published
Abstract [en]

Hepatitis B vaccines do not generate protective immune responses in older adults as effectively as they do in children and young adults. Improved formulations of existing vaccines may have the potential to improve this. This study investigated the persistence of serum antibodies against hepatitis B surface antigens (anti-HBs) 3.1–3.5 years following primary vaccination with 3 doses of HBvaxPRO® or Engerix B™ in healthy adults aged ≥50 years who were further challenged with 1 dose of recombinant hepatitis B antigen. This was an open-label extension study. Individuals (N = 204) with a mean (standard deviation) age at enrollment of 63.7 (7.0) years receiving HBvaxPRO® or Engerix B™ in a randomized, double-blind primary study were challenged with 1 dose of HBvaxPRO® (10 μg). Anti-HBs were measured pre- and 30 days post-challenge. 45.5% (34.8, 56.4 [95% CI]) of individuals who received HBvaxPRO® in the per protocol set (PPS) had anti-HBs titers ≥10 mIU/mL pre-challenge and 85.2% (76.1, 91.9) 1-month post-challenge. In those who received Engerix B™ in the primary vaccination series, the results were 58.8% (48.6, 68.5) and 88.3% (80.5, 93.8), respectively. The challenge dose of HBvaxPRO® was generally well tolerated. Subjects aged ≥50 years receiving a challenge dose of HBvaxPRO® demonstrated immune memory against hepatitis B 3 years after a 3-dose primary. The safety profile of this challenge dose of HBvaxPRO® was consistent with the well-established safety profile of the vaccine HBvaxPRO®.

Place, publisher, year, edition, pages
2015. Vol. 11, no 7, 1709-1716 p.
Keyword [en]
adult, hepatitis B, immunity, persistence, vaccination, AE, adverse event, anti-HBs, antibody to HBsAg, CI, confidence interval, GMT, geometric mean titer, HBsAg, hepatitis B surface antigen, PPS, per protocol set, SAE, serious adverse event, SAS, safety analysis set, SD, standard deviation, SPR, seroprotection rate
National Category
Immunology in the medical area Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-107076DOI: 10.1080/21645515.2015.1019187ISI: 000357412800030PubMedID: 25996838OAI: oai:DiVA.org:umu-107076DiVA: diva2:874232
Available from: 2015-11-26 Created: 2015-08-18 Last updated: 2015-11-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ahlm, Clas
By organisation
Infectious Diseases
In the same journal
Human Vaccines & Immunotherapeutics
Immunology in the medical areaMicrobiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link