umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Show others and affiliations
2012 (English)In: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 8, no 6, 1102-1113 p.Article in journal (Refereed) Published
Abstract [en]

Immunoglobulin A nephropathy (IgAN) is a leading cause of chronic kidney disease, frequently associated with hypertension and renal inflammation. ω-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in fish oil (FO) improve kidney function in animal models, but have inconsistent metabolic effects in humans. Oxylipin profiles in serum from IgAN patients supplemented with either FO or corn oil (CO) placebo were analyzed by liquid chromatography coupled to tandem mass spectrometry. EPA cyclooxygenase and lipoxygenase metabolites, and EPA and DHA epoxides and diols were increased in response to FO supplementation, as were total epoxides and epoxide/diol ratios. Several of these metabolites were drivers of separation as assessed by multivariate analysis of FO patients pre- vs. post-supplementation, including 17,18-dihydroxyeicosatrienoic acid, prostaglandin D3, prostagalandin E3, Resolvin E1, 12-hydroxyeicosapentaenoic acid, and 10(11)-epoxydocosapentaenoic acid. In patients whose proteinuria improved, plasma total oxylipins as well as several hydroxyoctadecadienoic acids, hydroxyeicosatetraenoic acids, and leukotriene B4 metabolites were among the metabolites that were significantly lower than in patients whose proteinuria either did not improve or worsened. These data support the involvement of oxylipins in the inflammatory component of IgAN as well as the potential use of oxylipin profiles as biomarkers and for assessing responsiveness to ω-3 fatty acid supplementation in IgAN patients.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2012. Vol. 8, no 6, 1102-1113 p.
Keyword [en]
DHA; EPA; Eicosanoids; Inflammation; Kidney function; Metabolomics; Oxylipins; Signaling lipids; ω-3 fatty acid
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-112055DOI: 10.1007/s11306-012-0417-5OAI: oai:DiVA.org:umu-112055DiVA: diva2:875257
Available from: 2015-12-01 Created: 2015-12-01 Last updated: 2015-12-01

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Nording, Malin
By organisation
Department of Chemistry
In the same journal
Metabolomics
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link