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Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi. Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi. Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar.
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Infektionssjukdomar. (Arcum)
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Klinisk kemi.
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2015 (Engelska)Ingår i: Journal of Infectious Diseases, ISSN 0022-1899, E-ISSN 1537-6613, Vol. 212, nr 7, s. 1061-1069Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background. Thrombocytopenia is a common finding during viral hemorrhagic fever, which includes hemorrhagic fever with renal syndrome (HFRS). The 2 main causes for thrombocytopenia are impaired thrombopoiesis and/or increased peripheral destruction of platelets. In addition, there is an increased intravascular coagulation risk during HFRS, which could be due to platelet activation. Methods. Thrombopoiesis was determined by quantification of platelet counts, thrombopoietin, immature platelet fraction, and mean platelet volume during HFRS. The in vivo platelet activation was determined by quantification of soluble P-selectin (sP-selectin) and glycoprotein VI (sGPVI). The function of circulating platelets was determined by ex vivo stimulation followed by flow cytometry analysis of platelet surface-bound fibrinogen and P-selectin exposure. Intravascular coagulation during disease was determined by scoring for disseminated intravascular coagulation (DIC) and recording thromboembolic complications. Results. The levels of thrombopoietin, immature platelet fraction, and mean platelet volume all indicate increased thrombopoiesis during HFRS. Circulating platelets had reduced ex vivo function during disease compared to follow-up. Most interestingly, we observed significantly increased in vivo platelet activation in HFRS patients with intravascular coagulation (DIC and thromboembolic complications) as shown by sP-selectin and sGPVI levels. Conclusions. HFRS patients have increased thrombopoiesis and platelet activation, which contributes to intravascular coagulation.

Ort, förlag, år, upplaga, sidor
Oxford University Press, 2015. Vol. 212, nr 7, s. 1061-1069
Nyckelord [en]
disseminated intravascular coagulation, hantavirus, hemorrhagic fever with renal syndrome, platelets, thrombosis, viral hemorrhagic fever
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Infektionsmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-111492DOI: 10.1093/infdis/jiv161ISI: 000363191300007PubMedID: 25762786OAI: oai:DiVA.org:umu-111492DiVA, id: diva2:875966
Tillgänglig från: 2015-12-02 Skapad: 2015-11-13 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Connolly-Andersen, Anne-MarieSundberg, ErikAhlm, ClasHultdin, JohanBaudin, MariaNilsson, Sofie

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Connolly-Andersen, Anne-MarieSundberg, ErikAhlm, ClasHultdin, JohanBaudin, MariaNilsson, Sofie
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VirologiInfektionssjukdomarKlinisk kemi
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Journal of Infectious Diseases
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologiInfektionsmedicin

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