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Is Lipoprotein-Associated Phospholipase A2a Link between Inflammation and Subclinical Atherosclerosis inRheumatoid Arthritis?
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Clinical Physiology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Reumatology.
Department of Rheumatology, Sunderby Hospital, Luleå, Sweden.
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2015 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, 673018Article in journal (Refereed) Published
Abstract [en]

Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Methods. Patients from northern Sweden diagnosed with early RA were consecutively recruited into an ongoing prospective study. From these, all patients <= 60 years (n = 71) were included for measurements of subclinical atherosclerosis at inclusion (T0) and five years later (T5). Forty age-and sex-matched controls were included. The patients were clinically assessed, SCORE, Reynolds Risk Score, and Larsen score were calculated, and blood samples were drawn from all individuals at T0 and T5. Results. There was no significant difference in the level of Lp-PLA2 between patients with RA and controls (p > 0.05). In simple linear regression models among patients with RA, Lp-PLA2 at T0 was significantly associated with intima media thickness (IMT) at T0 and T5, flow mediated dilation (FMD) at T0 and T5, ever smoking, male sex, HDL-cholesterol (inversely), non-HDL-cholesterol, SCORE, Reynolds Risk Score, and Larsen score (p < 0.05). Conclusion. In this cohort of patients with early RA, the concentration of Lp-PLA2 was associated with both subclinical atherosclerosis and disease severity.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2015. 673018
Keyword [en]
phospholipase, cardiovascular disease, Lp-PLA2
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-111521DOI: 10.1155/2015/673018ISI: 000363154200001PubMedID: 26504820OAI: oai:DiVA.org:umu-111521DiVA: diva2:876363
Available from: 2015-12-03 Created: 2015-11-13 Last updated: 2017-12-01Bibliographically approved

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Södergren, AnnaKarp, KjellBengtsson, ChristineRantapää-Dahlqvist, SolbrittWållberg-Jonsson, Solveig

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