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Ischemic heart disease among subjects with and without chronic obstructive pulmonary disease: ECG-findings in a population-based cohort study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.ORCID iD: 0000-0002-2574-479X
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
Göteborgs Universitet.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine.
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2015 (English)In: BMC Pulmonary Medicine, ISSN 1471-2466, E-ISSN 1471-2466, Vol. 15, 156Article in journal (Refereed) Published
Abstract [en]

Background: Cardiovascular comorbidity in COPD is common and contributes to increased mortality. A few population-based studies indicate that ischemic electrocardiogram (ECG)-changes are more prevalent in COPD, while others do not.

The aim of the present study was to estimate the presence of ischemic heart disease (IHD) in a population-based COPD-cohort in comparison with subjects without COPD.

Methods: All subjects with obstructive lung function (COPD, n = 993) were identified together with age- and sex-matched controls (non-COPD, n = 993) from population-based cohorts examined in 2002–04. In 2005, data from structured interview, spirometry and ECG were collected from 1625 subjects. COPD was classified into GOLD 1–4 after post-bronchodilator spirometry. Ischemic ECG-changes, based on Minnesota-coding, were classified according to the Whitehall criteria into probable and possible IHD.

Results: Self-reported IHD was equally common in COPD and non-COPD, and so were probable and possible ischemic ECG-changes according to Whitehall. After excluding subjects with restrictive spirometric pattern from the non-COPD-group, similar comparison with regard to presence of IHD performed between those with COPD and those with normal lung-function did neither show any differences. There was a significant association between self-reported IHD (p = 0.007) as well as probable ischemic ECG-changes (p = 0.042), and increasing GOLD stage. In COPD there was a significant association between level of FEV1 percent of predicted and self-reported as well as probable ischemic ECG-changes, and this association persisted for self-reported IHD also after adjustment for sex and age.

Conclusion: In this population-based study, self-reported IHD and probable ischemic ECG-changes were associated with COPD disease severity assessed by spirometry.

Place, publisher, year, edition, pages
Umeå, 2015. Vol. 15, 156
Keyword [en]
Comorbidity, Epidemiology, Coronary disease, Respiratory diseases
National Category
Cardiac and Cardiovascular Systems
Research subject
URN: urn:nbn:se:umu:diva-112463DOI: 10.1186/s12890-015-0149-1PubMedID: 26637314OAI: diva2:878049
Available from: 2015-12-08 Created: 2015-12-08 Last updated: 2015-12-09Bibliographically approved

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Nilsson, UlfJohansson, BengtBlomberg, AndersLindberg, Anne
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