Umeå University's logo

umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Malmö, Sweden.
2015 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 110, no 1, p. 66-74Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Aims: Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes. The prevalence of NAFLD varies across populations of different ethnic backgrounds but the prevalence in Middle Eastern populations, which are at high risk of type 2 diabetes, is largely unknown. Using fatty liver index (FLI) as a proxy for NAFLD the aim was to calculate the odds of NAFLD (FLI >= 70) given country of origin and further to investigate the associations between ISI and FLI. Methods: In 2010-2012 we conducted a population-based study of individuals aged 30-75 years born in Iraq or Sweden, in whom anthropometrics, fasting blood samples and oral glucose tolerance tests were performed and sociodemography and lifestyle behaviors characterized. Results: A higher proportion of Iraqis (N = 1085) than Swedes (N = 605) had a high probability of NAFLD (FLI >= 70, 32.5 vs. 22.6%, p < 0.001, age-and sex-adjusted data) and ISI was more severely impaired (70.7 vs. 95.9%, p < 0.001). Independently of traditional risk factors for NAFLD, being born in Iraqi increased the risk of FLI >= 70 (OR 1.59: 95% CI 1.15, 2.20). Furthermore, country of birth presented a stronger association between ISI and FLI >= 70 in Iraqis than in Swedes (P-interaction = 0.019). Conclusions: Our data indicate that immigrants from Iraq are at higher risk of NAFLD. The finding that country of birth modifies the relationship of FLI with ISI, suggests that liver fat may be a stronger determinant of impaired insulin action and increased risk of type 2 diabetes in Iraqis than in Swedes.

Place, publisher, year, edition, pages
2015. Vol. 110, no 1, p. 66-74
Keywords [en]
Type 2 diabetes, Insulin sensitivity, Non-alcohol fatty liver disease, Middle East
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-112665DOI: 10.1016/j.diabres.2015.07.011ISI: 000365100800012PubMedID: 26278350Scopus ID: 2-s2.0-84943198653OAI: oai:DiVA.org:umu-112665DiVA, id: diva2:881789
Available from: 2015-12-11 Created: 2015-12-11 Last updated: 2023-03-23Bibliographically approved

Open Access in DiVA

fulltext(1534 kB)451 downloads
File information
File name FULLTEXT01.pdfFile size 1534 kBChecksum SHA-512
0124f831d5b93a7d67412c7c3c124e1f3e3985d0cbc6af5e9e5836ed0527e738d8ee31f543fbc511fa495b6615c5670eb225c57e47016b4a66fcec3223c65990
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Franks, Paul W.

Search in DiVA

By author/editor
Franks, Paul W.
By organisation
Medicine
In the same journal
Diabetes Research and Clinical Practice
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 451 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 415 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf