umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Validity and Responsiveness of At-Home Touch Screen Assessments in Advanced Parkinson's Disease
Show others and affiliations
2015 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 19, no 6, 1829-1834 p.Article in journal (Refereed) PublishedText
Abstract [en]

The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson's disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on unified PD rating scale (UPDRS) and 39-item PD questionnaire (PDQ-39) scales. In LCIG-naive patients, the mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non naive patients, there were no significant changes in the mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS, respectively. The trends of the test scores were similar to the trends of clinical rating scores but the dropout rate was high. Correlations betweenOTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS.

Place, publisher, year, edition, pages
2015. Vol. 19, no 6, 1829-1834 p.
Keyword [en]
Home assessment, levodopa infusion, Parkinson's, disease (PD), remote monitoring, telemedicine.
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:umu:diva-112657DOI: 10.1109/JBHI.2015.2468088ISI: 000364857000007PubMedID: 26285227OAI: oai:DiVA.org:umu-112657DiVA: diva2:881909
Available from: 2015-12-11 Created: 2015-12-11 Last updated: 2015-12-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Linder, Jan
By organisation
Department of Pharmacology and Clinical Neuroscience
In the same journal
IEEE journal of biomedical and health informatics
Other Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 22 hits
ReferencesLink to record
Permanent link

Direct link