Hypothalamus-Pituitary-Adrenal Axis Hypersuppression Is Associated with Gastrointestinal Symptoms in Major Depression
2016 (English)In: Journal of neurogastroenterology and motility, ISSN 2093-0879, Vol. 22, no 2, 292-303 p.Article in journal (Refereed) Published
Background/Aims: Gastrointestinal symptoms and hypothalamus-pituitary-adrenal (HPA) axis dysfunction are frequently observed in patients with major depression. The primary aim of the study was to investigate the relationship between HPA-axis function and self-perceived functional gastrointestinal symptoms in major depression.
Methods: Patients with major depression (n = 73) and controls representative of the general population (n = 146) underwent a weight-adjusted very low dose dexamethasone suppression test (DST). Patients and controls completed the Gastrointestinal Symptom Rating Scale-Irritable Bowel Syndrome (GSRS-IBS) and the Hospital Anxiety Depression Scale. Medical records of the patients were screened over a ten year period for functional gastrointestinal disorder and pain conditions.
Results: Patients with high GSRS-IBS scores (above median) exhibited HPA-axis hypersuppression more often than controls (defined by the lowest 10% cutoff of the post-DST cortisol values among controls, adjusted OR 7.25, CI 1.97-26.7) whereas patients with low GSRS-IBS scores did not differ from controls concerning their post-DST cortisol values. Patients who had consulted primary care for functional gastrointestinal disorder (P= 0.039), lumbago (P = 0.006) and chronic multifocal pain (P= 0.057) also exhibited an increased frequency of hypersuppression.
Conclusions: HPA-axis hypersuppression is associated with functional gastrointestinal symptoms in patients with major depression.
Place, publisher, year, edition, pages
2016. Vol. 22, no 2, 292-303 p.
Depression, Dexamethasone, Hypocortisolism, Hypothalamo-hypophyseal system, Irritable bowel syndrome
IdentifiersURN: urn:nbn:se:umu:diva-112721DOI: 10.5056/jnm15064ISI: 000373662200016PubMedID: 26507800OAI: oai:DiVA.org:umu-112721DiVA: diva2:882261