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Subjective memory impairment in older adults predicts future dementia independent of baseline memory performance: Evidence from the Betula prospective cohort study
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Social Sciences, Department of Psychology. Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR).
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.ORCID iD: 0000-0002-8114-7615
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI). Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 11, 1385-1392 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: The objective was to examine whether subjective memory impairment (SMI) predicts all-cause dementia or Alzheimer's disease (AD) in a population-based study with long-term follow-up (median = 10 years).

METHODS: A total of 2043 initially dementia-free participants (≥ 60 years) made three memory ratings ("compared with others", "compared with five years ago", and "complaints from family/friends") at baseline. During follow-up, 372 participants developed dementia (208 with AD).

RESULTS: Cox regression revealed that subjective memory impairment ratings predicted all-cause dementia in models adjusting for age and sex (hazard ratio or HR from 2.04 to 3.94), with even higher values for AD (HR from 2.29 to 5.74). The result persisted in models including other covariates, including baseline episodic memory performance, and in analyses restricted to participants with long time to dementia diagnosis (≥ 5 years).

DISCUSSION: The findings underscore the usefulness of subjective memory assessment in combination with other factors in identifying individuals at risk for developing dementia.

Place, publisher, year, edition, pages
2015. Vol. 11, no 11, 1385-1392 p.
Keyword [en]
Subjective memory impairment, Objective memory, Dementia, Alzheimer's disease
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:umu:diva-112734DOI: 10.1016/j.jalz.2014.11.006ISI: 000365162900013PubMedID: 25667997OAI: oai:DiVA.org:umu-112734DiVA: diva2:882267
Available from: 2015-12-14 Created: 2015-12-14 Last updated: 2016-01-29Bibliographically approved

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Rönnlund, MichaelSundström, AnnaAdolfsson, RolfNilsson, Lars-Göran
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Department of PsychologyCentre for Demographic and Ageing Research (CEDAR)PsychiatryUmeå Centre for Functional Brain Imaging (UFBI)
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Alzheimer's & Dementia
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