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Pretreatment of lignocellulose: Formation of inhibitory by-products and strategies for minimizing their effects
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2016 (English)In: Bioresource Technology, ISSN 0960-8524, E-ISSN 1873-2976, Vol. 199, 103-112 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Biochemical conversion of lignocellulosic feedstocks to advanced biofuels and other commodities through a sugar-platform process involves a pretreatment step enhancing the susceptibility of the cellulose to enzymatic hydrolysis. A side effect of pretreatment is formation of lignocellulose-derived by-products that inhibit microbial and enzymatic biocatalysts. This review provides an overview of the formation of inhibitory by-products from lignocellulosic feedstocks as a consequence of using different pretreatment methods and feedstocks as well as an overview of different strategies used to alleviate problems with inhibitors. As technologies for biorefining of lignocellulose become mature and are transferred from laboratory environments to industrial contexts, the importance of management of inhibition problems is envisaged to increase as issues that become increasingly relevant will include the possibility to use recalcitrant feedstocks, obtaining high product yields and high productivity, minimizing the charges of enzymes and microorganisms, and using high solids loadings to obtain high product titers.

Place, publisher, year, edition, pages
2016. Vol. 199, 103-112 p.
Keyword [en]
Lignocellulose, Biorefining, Pretreatment, Inhibitors, Detoxification
National Category
Biochemistry and Molecular Biology Bioenergy
URN: urn:nbn:se:umu:diva-112646DOI: 10.1016/j.biortech.2015.10.009ISI: 000365047200013PubMedID: 26482946OAI: diva2:882304
Swedish Research Council, 621-2011-4388Bio4Energy
Available from: 2015-12-14 Created: 2015-12-11 Last updated: 2015-12-14Bibliographically approved

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Jonsson, Leif J.Martin, Carlos
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