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Synthesis of multiring fused 2‑pyridones via a nitrene insertion reaction: fluorescent modulators of α‑synuclein amyloid formation
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2015 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 17, no 24, 6194-6197 p.Article in journal, Letter (Refereed) Published
Abstract [en]

An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C−H amination reaction is reported. All the synthesized polyheterocycles were evaluated for their fluorescent properties and effect on α-synuclein amyloid formation.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2015. Vol. 17, no 24, 6194-6197 p.
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Chemical Sciences
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URN: urn:nbn:se:umu:diva-112810DOI: 10.1021/acs.orglett.5b03190ISI: 000366878300065PubMedID: 26650849OAI: oai:DiVA.org:umu-112810DiVA: diva2:882631
Available from: 2015-12-15 Created: 2015-12-15 Last updated: 2016-02-05Bibliographically approved

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Singh, PardeepChorell, ErikKrishnan, K SyamKindahl, TomasÅdén, JörgenWittung-Stafshede, PernillaAlmqvist, Fredrik
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