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Choline acetyltransferase and the nicotinic acetylcholine receptor AChR alpha 7 in experimental myositis
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB).
2015 (English)In: International Immunopharmacology, ISSN 1567-5769, E-ISSN 1878-1705, Vol. 29, no 1, 189-194 p.Article in journal (Refereed) PublishedText
Abstract [en]

It is not known to what extent a non-neuronal cholinergic system is involved in myositis (muscle inflammation) evoked by marked muscle overuse. Therefore, in the present study, a recently established rabbit myositis model was used and the expression patterns of ChAT and nicotinic acetylcholine receptor AChR alpha 7 (alpha 7nAChR) were evaluated. Immunohistochemistry and in situ hybridization were used. The model leads to myositis including occurrence of muscle fiber necrosis. It was found that the infiltrating white blood cells as well the walls of small blood vessels exhibited immunoreactivity for both ChAT and alpha 7nAChR There was also pronounced immunoreactivity for these in the white blood cells that had coalesced within the necrotic muscle fibers. The findings show that there is a presence of a non-neuronal cholinergic system in the situation of muscle inflammation. Cholinergic effects may be highly involved in the inflammation-modifying events that occur in muscle overuse.

Place, publisher, year, edition, pages
2015. Vol. 29, no 1, 189-194 p.
Keyword [en]
Myositis, Muscle overuse, Cholinergic system, Necrosis, White blood cells
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:umu:diva-113440DOI: 10.1016/j.intimp.2015.05.053ISI: 000365365500032PubMedID: 26086364OAI: oai:DiVA.org:umu-113440DiVA: diva2:885364
Conference
4th International Symposium on Non-neuronal Acetylcholine
Available from: 2015-12-18 Created: 2015-12-18 Last updated: 2015-12-18Bibliographically approved

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Spang, ChristophForsgren, Sture
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Department of Integrative Medical Biology (IMB)
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ReferencesLink to record
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