Increased Level of Epidermal Growth Factor Receptor in Oral Lichen Planus
Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Oral lichen planus (OLP) is the most common noninfectious oral mucosal disease that 1-2 percent of the general adult population suffers from. The etiology of OLP is not yet fully understood. OLP is classified as a pre-malignant disorder by World Health Organization (WHO) but the exact carcinogenetic mechanism is still undiscovered. Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein. Under normal conditions EGFR is mostly expressed in the basal cell layer of the epidermis. EGFR is overexpressed in squamous cell carcinoma head and neck (SCCHN). Overexpression of EGFR is also correlated with a poor diagnosis. To examine whether EGFR expression in OLP is more similar to healthy controls or the observed overexpression in SCCHN, biopsies for this study were collected and treated for histological analysis and graded using a “quickscore” (QS) system. Our hypothesis was that the expression of EGFR would differ between OLP lesions and healthy oral controls. The results confirmed the hypothesis with a significantly higher expression of EGFR in OLP compared with healthy oral mucosa. The null hypothesis that there would be no difference was rejected. In addition to these results, large variations of EGFR expression between the OLP biopsies were observed. A hypothesis is that it could possibly indicate a difference in prognosis. To determine what an EGFR overexpression in OLP implies-and to discover the carcinogenetic mechanism--further studies are needed.
Place, publisher, year, edition, pages
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-113642OAI: oai:DiVA.org:umu-113642DiVA: diva2:886268
Ebrahimi, MajidDanielsson, Karin