Expression of P16 in OLP and GLP Compared to Normal Mucosa
Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Lichen Planus is an inflammatory autoimmune disease, affecting oral and genital mucosa and skin. Oral Lichen Planus is considered a premalignant condition according to the WHO.
The p16 tumor suppressor protein can act as an inhibitor of cyclin dependent kinases 4 and 6 to down regulate the cell cycle progression. Since the discovery of p16 in 1993, several immunohistochemical studies have been done worldwide evaluating its expression as a pivotal marker in varies forms of human cancers but yet few studies are published around the role of p16 in OLP.
The aim of this study was to evaluate the differences between the expression pattern of p16 in healthy oral mucosa compared to OLP, and healthy genital mucosa compared to genital LP in order to see how this gene acts in these different tissue conditions. We investigated p16 expression in 76 OLP, 34 GLP, 12 healthy oral mucosa and 9 healthy genital mucosa samples. An immunostaining with quick-score higher than 0 was classified as positive outcome for p16 expression.
Data from the study revealed that p16 is highly expressed in both OLP and genital LP samples with 96% and 85% respectively, while the expression of p16 is relatively low in oral control specimens with 33%. Although, genital control samples showed a positive rate of 89%. Significant difference in positivity of p16 expression was noticed between normal oral mucosa and OLP (p = 0.000). No statistically significant difference could be registered between normal genital mucosa and genital LP (p = 0.054).
Place, publisher, year, edition, pages
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-113646OAI: oai:DiVA.org:umu-113646DiVA: diva2:886290
Ebrahimi, MajidDanielsson, Karin