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Sonotrombolys kan förstärka effekten av intravenös trombolys
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
2015 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 112, C9LFArticle, review/survey (Refereed) Published
Abstract [sv]

Intravenous thrombolysis has been a break-through for treatment of acute ischemic stroke. However, total recanalization is only achieved in 18%. Sonothrombolysis aims at enhancing the recanalization effect by adding continuous transcranial ultrasound. Sonothrombolysis may facilitate the recanalization rate without increased risk of intracerebral hemorrhage. This further results in decreased risk of disability compared with only intravenous thrombolysis. Intravenously applied micro-bubbles is an additive treatment to sonothrombolysis which might further increase the recanalization rate but perhaps at the expense of increased risk of intracerebral hemorrhage. In a case-series at Umeå Stroke Center, we report the results of the first 20 ischemic stroke patients treated with sonothrombolysis in Sweden. Our initial results look promising with recanalization rates similar to earlier published data. No intracerebral hemorrhage occurred among our sonothrombolysed patients.

Place, publisher, year, edition, pages
2015. Vol. 112, C9LF
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:umu:diva-113953PubMedID: 25647105OAI: oai:DiVA.org:umu-113953DiVA: diva2:892005
Available from: 2016-01-08 Created: 2016-01-08 Last updated: 2016-03-09Bibliographically approved

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Gu, ThomasWester, PerJohansson, Elias
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