umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Obstetrics and Gynaecology.
2015 (English)In: Current Psychiatry Reports, ISSN 1523-3812, E-ISSN 1535-1645, Vol. 17, no 11, 92Article, review/survey (Refereed) Published
Abstract [en]

In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual cycles, the premenstrual dysphoric disorder (PMDD). In anovulatory cycles, no symptom or sex steroid increase occurs but symptoms return during progesterone/allo treatment. Allo is a potent GABA(A) receptor-modulating steroid and as such is expected to be calming and anxiolytic. A relation to negative mood is unexpected. However, this paradoxical effect can be induced by all GABA(A) receptor modulators in low concentrations whereas higher concentrations are calming. The severity of the mood symptoms relate to allo in an inverted U-shaped curve at endogenous luteal-phase serum concentrations. Allo's effects on the GABA(A) receptor can be antagonized by isoallopregnanolone (ISO), an antagonist to allo. ISO has also been used in a preliminary clinical trial on PMDD ameliorating symptoms with good effect in PMDD patients.

Place, publisher, year, edition, pages
2015. Vol. 17, no 11, 92
Keyword [en]
GABA(A) receptor-modulating steroids, Premenstrual dysphoric disorder, Mood symptoms
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-110501DOI: 10.1007/s11920-015-0627-4ISI: 000361741100007PubMedID: 26396092OAI: oai:DiVA.org:umu-110501DiVA: diva2:894551
Available from: 2016-01-15 Created: 2015-10-22 Last updated: 2016-01-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bäckström, TorbjörnBixo, MarieStrömberg, Jessica
By organisation
Obstetrics and Gynaecology
In the same journal
Current Psychiatry Reports
Psychiatry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 28 hits
ReferencesLink to record
Permanent link

Direct link