Amino acid building blocks for Fmoc solid-phase synthesis of peptides phosphocholinated at serine, threonine, and tyrosine
2013 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 78, no 6, 2715-2719 p.Article in journal (Refereed) Published
Phosphocholination of eukaryotic host cell proteins has recently been identified as a novel post-translational modification important for bacterial pathogenesis. Here, we describe the first straightforward synthetic strategy for peptides containing phosphocholinated serine, threonine, or tyrosine residues using preformed functional amino acid building blocks, fully compatible with standard Fmoc solid-phase peptide synthesis.
Place, publisher, year, edition, pages
2013. Vol. 78, no 6, 2715-2719 p.
enzymes, nucleotides, phosphocholination, protein modifications
Research subject Biorganic Chemistry
IdentifiersURN: urn:nbn:se:umu:diva-114327DOI: 10.1021/jo302587gISI: 000316375300057PubMedID: 23373758OAI: oai:DiVA.org:umu-114327DiVA: diva2:895048