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Dynamic fMRI brain connectivity: A study of the brain’s large-scale network dynamics
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Science and Technology, Department of Physics. Karolinska Institutet, Department of Clinical Neuroscience.
2016 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Approximately 20% of the body’s energy consumption is ongoingly consumed by the brain, where the main part is due to the neural activity, which is only increased slightly when doing a demanding task. This ongoingly neural activity are studied with the so called resting-state fMRI, which mean that the neural activity in the brain is measured for participants with no specific task. These studies have been useful to understand the neural function and how the neural networks are constructed and cooperate. This have also been helpful in several clinical research, for example have differences been identified between bipolar disorder and major depressive disorder. Recent research has focused on temporal properties of the ongoing activity and it is well known that neural activity occurs in bursts. In this study, resting-state fMRI data and temporal graph theory is used to develop a point based method (PBM) to quantify these bursts at a nodal level. By doing this, the bursty pattern can be further investigated and the nodes showing the most bursty pattern (i.e hubs) can be identified. The method developed shows a robustness regarding several different aspects. In the method is two different variance threshold algorithms suggested. One local variance threshold (LVT) based on the individual variance of the edge time-series and one global variance threshold (GVT) based on the variance of all edges time-series, where the GVT shows the highest robustness. However, the choice of threshold needs to be adapted for the aims of the current study. Finally, this method ends up in a new measure to quantify this bursty pattern named bursty centrality. The derived temporal graph theoretical measure was correlated with traditional static graph properties used in resting state and showed a low but significant correlation. By applying this method on resting-state fMRI data for 32 young adults was it possible to identify regions of the brain that showed the most dynamic properties, these regions differed between the two thresholding algorithms

Place, publisher, year, edition, pages
2016. , 47 p.
Keyword [en]
fMRI; dynamic functional connectivity; burst; burstiness; resting-state; temporal graph theory; networks; connectome; dynamic brain connectivity
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:umu:diva-114493OAI: oai:DiVA.org:umu-114493DiVA: diva2:896404
Subject / course
Examensarbete i teknisk fysik
Educational program
Master of Science Programme in Engineering Physics
Presentation
2016-01-15, Universitetsklubben, Umeå Universitet, Umeå, 08:00 (English)
Supervisors
Examiners
Available from: 2016-02-01 Created: 2016-01-21 Last updated: 2016-02-01Bibliographically approved

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Brantefors, Per
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Department of Radiation SciencesDepartment of Physics
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