umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort)
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Show others and affiliations
2015 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 7, no 12, 10100-10115 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Exposure to polyunsaturated fatty acids (PUFA) influences immune function and may affect the risk of allergy development. Long chain PUFAs are produced from dietary precursors catalyzed by desaturases and elongases encoded by FADS and ELOVL genes. In 211 subjects, we investigated whether polymorphisms in the FADS gene cluster and the ELOVL2 gene were associated with allergy or PUFA composition in serum phospholipids in a Swedish birth-cohort sampled at birth and at 13 years of age; allergy was diagnosed at 13 years of age. Minor allele carriers of rs102275 and rs174448 (FADS gene cluster) had decreased proportions of 20:4 n-6 in cord and adolescent serum and increased proportions of 20:3 n-6 in cord serum as well as a nominally reduced risk of developing atopic eczema, but not respiratory allergy, at 13 years of age. Minor allele carriers of rs17606561 in the ELOVL2 gene had nominally decreased proportions of 20:4 n-6 in cord serum but ELOVL polymorphisms (rs2236212 and rs17606561) were not associated with allergy development. Thus, reduced capacity to desaturase n-6 PUFAs due to FADS polymorphisms was nominally associated with reduced risk for eczema development, which could indicate a pathogenic role for long-chain PUFAs in allergy development.

Place, publisher, year, edition, pages
MPDI , 2015. Vol. 7, no 12, 10100-10115 p.
Keyword [en]
long chain polyunsaturated fatty acids, arachidonic acid, phospholipids, umbilical cord serum, single nucleotide polymorphism, fatty acid desaturase, FADS, elongase, ELOVL2, nutrigenetics, allergy, atopic eczema, respiratory allergy, BAS birth cohort
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:umu:diva-114636DOI: 10.3390/nu7125521ISI: 000367052200028PubMedID: 26633493OAI: oai:DiVA.org:umu-114636DiVA: diva2:900001
Available from: 2016-02-03 Created: 2016-01-25 Last updated: 2017-11-30Bibliographically approved

Open Access in DiVA

fulltext(1520 kB)57 downloads
File information
File name FULLTEXT01.pdfFile size 1520 kBChecksum SHA-512
a05100bff08653089635d59aa4022c6fbe6796927878dfb92f45655c3ab72fd985891e40b3c1d92523d01bbd7be87ddb7d8e0a1a672218c0be54dcaa60ecb6ad
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Sandin, Anna

Search in DiVA

By author/editor
Sandin, Anna
By organisation
Paediatrics
In the same journal
Nutrients
Nutrition and Dietetics

Search outside of DiVA

GoogleGoogle Scholar
Total: 57 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 94 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf