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Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity
Department of Occupational and Public Health Sciences, University of Gävle.
Umeå University, Faculty of Social Sciences, Department of Psychology.
Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark.
Danish Research Centre for Chemical Sensitivities, Copenhagen University Hospital Gentofte.
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2016 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 89, no 1, 79-88 p.Article in journal (Refereed) PublishedText
Abstract [en]

Purpose: Multiple chemical sensitivity (MCS) is a prevalent medically unexplained symptom characterized by symptom reactions to everyday chemical exposure below hygienic thresholds. The aim of this study was to investigate the expressions of hyper-reactivity in MCS during whole-body exposure to low concentrations of the odorant n-butanol.

Methods: We exposed 18 participants with MCS and 18 non-ill controls to a low concentration of the odorantn-butanol using an exposure chamber. The first 10 min constituted blank exposure, after which then-butanol concentration increased and reached a plateau at 11.5 mg/m3.

Results: MCS participants, compared with controls, reported greater perceived odor intensities, more unpleasantness to the exposure and increasing symptoms over time. MCS participants also expressed higher pulse rate and lower pulse rate variability than controls did. No group differences were found for breathing rate or tonic electrodermal activity responses.

Conclusions: We conclude that MCS sufferers differ from healthy controls in terms of autonomic responses, symptoms and chemosensory perception during chemical exposure.

Place, publisher, year, edition, pages
Springer, 2016. Vol. 89, no 1, 79-88 p.
Keyword [en]
Multiple chemical sensitivity, Chemical intolerance, Environmental intolerance, Olfaction, Autonomic rvous system, ROGATIS LR, 1976, BRITISH JOURNAL OF PSYCHIATRY, V128, P280 tthoeft Michael, 2006, JOURNAL OF ABNORMAL PSYCHOLOGY, V115, P397 rie Thi Dao Tran, 2013, INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, V216
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Other Health Sciences
URN: urn:nbn:se:umu:diva-116751DOI: 10.1007/s00420-015-1053-yISI: 000368807400008PubMedID: 25917753OAI: diva2:904724
Available from: 2016-02-19 Created: 2016-02-11 Last updated: 2016-02-23Bibliographically approved

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Claeson, Anna-SaraLind, NinaNordin, Steven
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