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L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles
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2016 (English)In: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 12, no 3, 301-306 p.Article in journal, Letter (Refereed) PublishedText
Abstract [en]

Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn2+ and l-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.

Place, publisher, year, edition, pages
2016. Vol. 12, no 3, 301-306 p.
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Cancer and Oncology
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URN: urn:nbn:se:umu:diva-116741DOI: 10.1002/smll.201502545ISI: 000368707800003PubMedID: 26619158OAI: oai:DiVA.org:umu-116741DiVA: diva2:904821
Available from: 2016-02-19 Created: 2016-02-11 Last updated: 2016-02-24Bibliographically approved

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Sandvig, Axel
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Department of Pharmacology and Clinical Neuroscience
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