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Electroencephalographic features of convulsive epilepsy in Africa: A multicentre study of prevalence, pattern and associated factors
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Epidemiology and Global Health. MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, P.O. Box 2 Cornhoek 1360, Johannesburg, South Africa.
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2016 (English)In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 127, no 2, 1099-1107 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objective: We investigated the prevalence and pattern of electroencephalographic (EEG) features of epilepsy and the associated factors in Africans with active convulsive epilepsy (ACE).

Methods: We characterized electroencephalographic features and determined associated factors in a sample of people with ACE in five African sites. Mixed-effects modified Poisson regression model was used to determine factors associated with abnormal EEGs.

Results: Recordings were performed on 1426 people of whom 751 (53%) had abnormal EEGs, being an adjusted prevalence of 2.7 (95% confidence interval (95% CI), 2.5–2.9) per 1000. 52% of the abnormal EEG had focal features (75% with temporal lobeinvolvement). The frequency and pattern of changes differed with site. Abnormal EEGs were associated with adverse perinatal events (risk ratio (RR) = 1.19 (95% CI, 1.07–1.33)), cognitive impairments (RR = 1.50 (95% CI, 1.30–1.73)), use of anti-epilepticdrugs (RR = 1.25 (95% CI, 1.05–1.49)), focal seizures (RR = 1.09 (95% CI, 1.00–1.19)) and seizure frequency (RR = 1.18 (95% CI, 1.10–1.26) for daily seizures; RR = 1.22 (95% CI, 1.10–1.35) for weekly seizures and RR = 1.15 (95% CI, 1.03–1.28) for monthly seizures)).

Conclusions: EEG abnormalities are common in Africans with epilepsy and are associated with preventable risk factors.

Significance: EEG is helpful in identifying focal epilepsy in Africa, where timing of focal aetiologies is problematic and there is a lack of neuroimaging services.

Place, publisher, year, edition, pages
2016. Vol. 127, no 2, 1099-1107 p.
Keyword [en]
Electroencephalographic features, Active convulsive epilepsy, Risk factors, Africa
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:umu:diva-116732DOI: 10.1016/j.clinph.2015.07.033ISI: 000368439100026OAI: oai:DiVA.org:umu-116732DiVA: diva2:904846
Available from: 2016-02-19 Created: 2016-02-11 Last updated: 2016-02-24Bibliographically approved

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Wagner, Ryan G.
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