Pregnancy and childbirth in women with autoimmune hepatitis is safe, even in compensated cirrhosis
2016 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 51, no 4, 479-485 p.Article in journal (Refereed) PublishedText
Introduction: Autoimmune hepatitis (AIH) is a liver disease that primarily affects women. Many become ill during childbearing age, and medication can be lifelong. Few studies exist on pregnancy outcome in women with AIH.
Objectives: The aim was to assess the outcome of women with AIH and their children during pregnancy and postpartum.
Materials and methods: Sixty-four women from a well-characterised cohort with AIH filled out a questionnaire with information about their disease, miscarriage/abortion, pregnancies and potential birth defects in 2012. In 2004, 106 women answered the same questionnaire and their results were analysed along with the new questionnaires.
Results: One hundred and thirty-eight women have completed the questionnaire and 100 children have been born by 58 women. Fifty-seven women (41%) had cirrhosis. In 84% of the pregnancies, the AIH was stable or milder, 32% had an increase in activity postpartum. The proportion of preterm births (before week 38) was 22%, caesarean sections 17%, malformations 3%, and two children died. Twenty-three women with cirrhosis had children after diagnosis of cirrhosis but without more complications than for non-cirrhotic mothers. However, they did have a higher prevalence of caesarean sections.
Conclusion: Pregnancy and childbirth in AIH appear to be safe for both child and mother, even in women with compensated liver cirrhosis.
Place, publisher, year, edition, pages
Taylor & Francis, 2016. Vol. 51, no 4, 479-485 p.
Abortion, autoimmune, hepatitis, liver cirrhosis, pregnancy, pregnancy outcome, spontaneous
Obstetrics, Gynecology and Reproductive Medicine
IdentifiersURN: urn:nbn:se:umu:diva-116729DOI: 10.3109/00365521.2015.1115893ISI: 000368696900013OAI: oai:DiVA.org:umu-116729DiVA: diva2:904850