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Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
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2009 (Engelska)Ingår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, nr 24, s. 9779-9784Artikel i tidskrift (Refereegranskat) Published
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Abstract [en]

The Drosophila NF-kappa B transcription factor Relish is an essential regulator of antimicrobial peptide gene induction after Gram-negative bacterial infection. Relish is a bipartite NF-kappa B precursor protein, with an N-terminal Rel homology domain and a C-terminal I kappa B-like domain, similar to mammalian p100 and p105. Unlike these mammalian homologs, Relish is endoproteolytically cleaved after infection, allowing the N-terminal NF-kappa B module to translocate to the nucleus. Signal-dependent activation of Relish, including cleavage, requires both the Drosophila I kappa B kinase (IKK) and death-related ced-3/Nedd2-like protein (DREDD), the Drosophila caspase-8 like protease. In this report, we show that the IKK complex controls Relish by direct phosphorylation on serines 528 and 529. Surprisingly, these phosphorylation sites are not required for Relish cleavage, nuclear translocation, or DNA binding. Instead they are critical for recruitment of RNA polymerase II and antimicrobial peptide gene induction, whereas IKK functions noncatalytically to support Dredd-mediated cleavage of Relish.

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National Academy of Sciences , 2009. Vol. 106, nr 24, s. 9779-9784
Nyckelord [en]
Drosophila immunity, innate immunity, NF-kappa B, caspase
Nationell ämneskategori
Mikrobiologi inom det medicinska området
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URN: urn:nbn:se:umu:diva-115994DOI: 10.1073/pnas.0812022106ISI: 000267045500043PubMedID: 19497884OAI: oai:DiVA.org:umu-115994DiVA, id: diva2:906887
Tillgänglig från: 2016-02-25 Skapad: 2016-02-08 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Stöven, SvenjaSilverman, Neal

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Proceedings of the National Academy of Sciences of the United States of America
Mikrobiologi inom det medicinska området

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