umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Bacterial flora and the epidemiology of staphylococcus aureus in the nose among patients with symptomatic nasal septal perforations
Umeå University, Faculty of Medicine, Department of Odontology, Dental Technology/Dental Materials Science.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Show others and affiliations
2016 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 136, no 6, 620-625 p.Article in journal (Refereed) Published
Abstract [en]

Conclusions Patients with symptomatic perforations of the nasal septum had a high prevalence of S. aureus in the nasal mucosa. Pulsed field gel electrophoresis (PFGE) analysis revealed a high genetic heterogeneity of S. aureus among both patients and controls. This indicates that presence of different strains of S. aureus can maintain a chronic inflammation in symptomatic nasal septal perforations. Objective The purpose of this study was to investigate the microbial flora around nasal septal perforations in patients having severe symptoms regarding bleeding, obstruction, and crustation associated with their perforation. Methods Twenty-five patients with untreated symptomatic nasal septal perforations were included. For culture, swabs around the perforations were collected. Bacteria were identified with standard laboratory techniques including a MALDI-TOF mass spectrometer. Epidemiological analysis was done using PFGE protocols. Bacteriological data were compared with data from a healthy control group. Results Staphylococcus aureus was present in the mucosa surrounding the nasal perforation significantly more often (p < 0.0001) in the patients (88%) compared to a control group (13%). Corynebacterium spp. and Propionibacterium spp. were significantly more frequently identified in the control group. The PFGE analysis of S. aureus strains revealed a high genetic heterogeneity and no specific S. aureus genotypes were associated with septal perforation.

Place, publisher, year, edition, pages
2016. Vol. 136, no 6, 620-625 p.
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:umu:diva-117369DOI: 10.3109/00016489.2016.1139743ISI: 000375483400015PubMedID: 26852671OAI: oai:DiVA.org:umu-117369DiVA: diva2:907460
Available from: 2016-02-29 Created: 2016-02-29 Last updated: 2016-07-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hulterström, Anna KarinSellin, MatsMonsen, TorWiderström, MicaelGurram, Bharath KumarBerggren, Diana
By organisation
Dental Technology/Dental Materials ScienceDepartment of Clinical MicrobiologyOtorhinolaryngology
In the same journal
Acta Oto-Laryngologica
Otorhinolaryngology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 56 hits
ReferencesLink to record
Permanent link

Direct link