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Microspheres and Nanotechnology for Drug Delivery.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2016 (English)In: Developments in ophthalmology, ISSN 1662-2790, Vol. 55Article in journal (Refereed) Published
Abstract [en]

Ocular drug delivery to the posterior segment of the eye can be accomplished by invasive drug injections into different tissues of the eye and noninvasive topical treatment. Invasive treatment involves the risks of surgical trauma and infection, and conventional topical treatments are ineffective in delivering drugs to the posterior segment of the eye. In recent years, nanotechnology has become an ever-increasing part of ocular drug delivery. In the following, we briefly review microspheres and nanotechnology for drug delivery to the eye, including different forms of nanotechnology such as nanoparticles, microparticles, liposomes, microemulsions and micromachines. The permeation barriers and anatomical considerations linked to ocular drug delivery are discussed and a theoretical overview on drug delivery through biological membranes is given. Finally, in vitro, in vivo and human studies of x03B3;-cyclodextrin nanoparticle eyedrop suspensions are discussed as an example of nanotechnology used for drug delivery to the eye.

Place, publisher, year, edition, pages
2016. Vol. 55
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-117371DOI: 10.1159/000434693PubMedID: 26501994OAI: diva2:907461
Available from: 2016-02-29 Created: 2016-02-29 Last updated: 2016-02-29

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Jóhannesson, Gauti
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