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Genealogy and gene trees
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2008 (English)In: Hereditas, ISSN 0018-0661, E-ISSN 1601-5223, Vol. 145, no 1, 20-27 p.Article in journal (Refereed) PublishedText
Abstract [en]

Heredity can be followed in persons or in genes. Persons can be identified only a few generations back, but simplified models indicate that universal ancestors to all now living persons have occurred in the past. Genetic variability can be characterized as variants of DNA sequences. Data are available only from living persons, but from the pattern of variation gene trees can be inferred by means of coalescence models. The merging of lines backwards in time leads to a MRCA (most recent common ancestor). The time and place of living for this inferred person can give insights in human evolutionary history. Demographic processes are incorporated in the model, but since culture and customs are known to influence demography the models used ought to be tested against available genealogy. The Icelandic data base offers a possibility to do so and points to some discrepancies. Mitochondrial DNA and Y chromosome patterns give a rather consistent view of human evolutionary history during the latest 100 000 years but the earlier epochs of human evolution demand gene trees with longer branches. The results of such studies reveal as yet unsolved problems about the sources of our genome.

Place, publisher, year, edition, pages
Oxford: Blackwell Publishing, 2008. Vol. 145, no 1, 20-27 p.
Keyword [en]
recent common ancestry, mitochondrial DNA, Y-chromosomes, evolution, individuals, humans, brain, size
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:umu:diva-117512DOI: 10.1111/j.0018-0661.2008.2041.xISI: 000254790700003PubMedID: 18439230OAI: oai:DiVA.org:umu-117512DiVA: diva2:908308
Available from: 2016-03-02 Created: 2016-03-01 Last updated: 2016-03-02Bibliographically approved

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Rasmuson, Marianne
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Department of Molecular Biology (Faculty of Medicine)
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ReferencesLink to record
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