umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Genetics of structural connectivity and information processing in the brain
Umeå universitet, Medicinska fakulteten, Umeå centrum för funktionell hjärnavbildning (UFBI). Aging Research Center, Karolinska Institutet and Stockholm University, 11330 Stockholm, Sweden.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Brain Structure and Function, ISSN 1863-2653, E-ISSN 1863-2661, Vol. 221, nr 9, s. 4643-4661Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Understanding the genetic factors underlying brain structural connectivity is a major challenge in imaging genetics. Here, we present results from genome-wide association studies (GWASs) of whole-brain white matter (WM) fractional anisotropy (FA), an index of microstructural coherence measured using diffusion tensor imaging. Data from independent GWASs of 355 Swedish and 250 Norwegian healthy adults were integrated by meta-analysis to enhance power. Complementary GWASs on behavioral data reflecting processing speed, which is related to microstructural properties of WM pathways, were performed and integrated with WM FA results via multimodal analysis to identify shared genetic associations. One locus on chromosome 17 (rs145994492) showed genome-wide significant association with WM FA (meta P value = 1.87 × 10(-08)). Suggestive associations (Meta P value <1 × 10(-06)) were observed for 12 loci, including one containing ZFPM2 (lowest meta P value = 7.44 × 10(-08)). This locus was also implicated in multimodal analysis of WM FA and processing speed (lowest Fisher P value = 8.56 × 10(-07)). ZFPM2 is relevant in specification of corticothalamic neurons during brain development. Analysis of SNPs associated with processing speed revealed association with a locus that included SSPO (lowest meta P value = 4.37 × 10(-08)), which has been linked to commissural axon growth. An intergenic SNP (rs183854424) 14 kb downstream of CSMD1, which is implicated in schizophrenia, showed suggestive evidence of association in the WM FA meta-analysis (meta P value = 1.43 × 10(-07)) and the multimodal analysis (Fisher P value = 1 × 10(-07)). These findings provide novel data on the genetics of WM pathways and processing speed, and highlight a role of ZFPM2 and CSMD1 in information processing in the brain.

Ort, förlag, år, upplaga, sidor
2016. Vol. 221, nr 9, s. 4643-4661
Nyckelord [en]
Imaging genetics, DTI, GWAS, Processing speed, Fractional anisotropy, Cognition
Nationell ämneskategori
Neurovetenskaper Medicinsk genetik
Identifikatorer
URN: urn:nbn:se:umu:diva-117931DOI: 10.1007/s00429-016-1194-0ISI: 000387657200023PubMedID: 26852023OAI: oai:DiVA.org:umu-117931DiVA, id: diva2:909451
Tillgänglig från: 2016-03-07 Skapad: 2016-03-07 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

Open Access i DiVA

fulltext(2991 kB)75 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 2991 kBChecksumma SHA-512
7e88789b0ef8d1028b4a29a348ad404c98f1c3c1b4c2d352931bffb9f3330fd25565353314ee105de261e7d97c7a0e2cf259917869fb56a1bd65e23ce38075bb
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Salami, AlirezaLundquist, AndersAdolfsson, RolfNyberg, Lars

Sök vidare i DiVA

Av författaren/redaktören
Salami, AlirezaLundquist, AndersAdolfsson, RolfNyberg, Lars
Av organisationen
Umeå centrum för funktionell hjärnavbildning (UFBI)StatistikPsykiatriInstitutionen för strålningsvetenskaperInstitutionen för integrativ medicinsk biologi (IMB)
I samma tidskrift
Brain Structure and Function
NeurovetenskaperMedicinsk genetik

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 75 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 210 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf