umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Impact of functional germline variants and a deletion polymorphism in APOBEC3A and APOBEC3B on breast cancer risk and survival in a Swedish study population
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Show others and affiliations
2016 (English)In: Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, E-ISSN 1432-1335, Vol. 142, no 1, 273-276 p.Article in journal (Refereed) PublishedText
Abstract [en]

Purpose: The C -> T mutation signature caused by APOBEC family members contributes to the development of breast cancer (BC). Also overexpression of APOBEC3B and a similar to 29. 5-kb deletion polymorphism between APOBEC3A and APOBEC3B have been associated with increased BC risk. Methods: We investigated in a population-based study, with 782 Swedish BC cases and 1559 controls, associations between potentially functional germline variants in APOBEC3A or APOBEC3B gene and BC risk and survival. Additionally, we identified deletion polymorphism carriers and explored possible associations with BC. Results: No evidence of association between any germline variant, including the deletion polymorphism, and BC risk or survival was observed. Only APOBEC3A promoter polymorphism rs5757402 was associated with low stage (OR = 0.69, 95 % CI 0.50-0.96, dominant model). Conclusion: The reported association between the deletion polymorphism and BC risk was not confirmed in the Swedish population, nor did any genotyped germline variant show any association with BC risk or survival.

Place, publisher, year, edition, pages
Springer, 2016. Vol. 142, no 1, 273-276 p.
Keyword [en]
Breast cancer, APOBEC3, Germline variants, Single-nucleotide polymorphism, Deletion polymorphism
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-118269DOI: 10.1007/s00432-015-2038-7ISI: 000370172900028PubMedID: 26320772OAI: oai:DiVA.org:umu-118269DiVA: diva2:912485
Available from: 2016-03-16 Created: 2016-03-14 Last updated: 2016-06-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johansson, RobertEnquist-Olsson, KerstinHenriksson, RogerLenner, Per
By organisation
Oncology
In the same journal
Journal of Cancer Research and Clinical Oncology
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 97 hits
ReferencesLink to record
Permanent link

Direct link