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TOR Signaling and Nutrient Sensing
Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Institut Jean-Pierre Bourgin, UMR 1318 INRA AgroParisTech, ERL CNRS 3559, Saclay Plant Sciences, Versailles 78026, France.
Umeå University, Faculty of Science and Technology, Department of Plant Physiology. Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC). (Hanson)ORCID iD: 0000-0002-5605-7984
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2016 (English)In: Annual Review of Plant Biology, ISSN 1543-5008, E-ISSN 1545-2123, Vol. 67, 261-285 p.Article, review/survey (Refereed) Published
Abstract [en]

All living organisms rely on nutrients to sustain cell metabolism and energy production, which in turn need to be adjusted based on available resources. The evolutionarily conserved target of rapamycin (TOR) protein kinase is a central regulatory hub that connects environmental information about the quantity and quality of nutrients to developmental and metabolic processes in order to maintain cellular homeostasis. TOR is activated by both nitrogen and carbon metabolites and promotes energy-consuming processes such as cell division, mRNA translation, and anabolism in times of abundance while repressing nutrient remobilization through autophagy. In animals and yeasts, TOR acts antagonistically to the starvation-induced AMP-activated kinase (AMPK)/sucrose nonfermenting 1 (Snf1) kinase, called Snf1-related kinase 1 (SnRK1) in plants. This review summarizes the immense knowledge on the relationship betweenTORsignaling and nutrients in nonphotosynthetic organisms and presents recent findings in plants that illuminate the crucial role of this pathway in conveying nutrient-derived signals and regulating many aspects of metabolism and growth.

Place, publisher, year, edition, pages
2016. Vol. 67, 261-285 p.
Keyword [en]
TOR kinase, SnRK1 kinase, nutrient signaling, sugars, nitrogen
National Category
Botany
Identifiers
URN: urn:nbn:se:umu:diva-118350DOI: 10.1146/annurev-arplant-043014-114648ISI: 000375803200011PubMedID: 26905651OAI: oai:DiVA.org:umu-118350DiVA: diva2:912560
Available from: 2016-03-16 Created: 2016-03-16 Last updated: 2016-08-02Bibliographically approved

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Dobrenel, ThomasHanson, Johannes
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Umeå Plant Science Centre (UPSC)Department of Plant Physiology
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