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Circulating 25-hydroxyvitamin D3 and survival after diagnosis with kidney cancer
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2015 (English)In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 24, no 8, 1277-1281 p.Article in journal (Refereed) Published
Abstract [en]

Prospective cohort studies have provided some evidence that circulating vitamin D is associated with risk of, and survival from, renal cell carcinoma (RCC), but it is unclear whether concentrations of vitamin D at the time of diagnosis of RCC are associated with prognosis. We conducted a case-cohort study of 630 RCC cases, including 203 deaths, from a multicenter case-control study in Eastern Europe. Vitamin D was assessed as 25-hydroxyvitamin D3 [25(OH)D3], and we used weighted Cox models to estimate hazard ratios (HR) and 95% confidence intervals (CI) by categories of season-adjusted 25(OH)D3. Higher concentrations of 25(OH)D3 were associated with lower risk of death after adjusting for stage, age, sex, and country (HR highest vs. lowest category 0.57; 95% CI, 0.34-0.97). The inverse associations of 25(OH)D3 with death were most notable among those who died from non-RCC causes and those diagnosed with early-stage disease. In summary, 25(OH)D3 concentration at diagnosis of RCC was inversely associated with all-cause mortality rates, but not specifically with RCC outcome.

Place, publisher, year, edition, pages
2015. Vol. 24, no 8, 1277-1281 p.
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Cancer and Oncology Public Health, Global Health, Social Medicine and Epidemiology
URN: urn:nbn:se:umu:diva-118590DOI: 10.1158/1055-9965.EPI-14-1351ISI: 000359320500018PubMedID: 26021552OAI: diva2:914232
Available from: 2016-03-23 Created: 2016-03-23 Last updated: 2016-03-23Bibliographically approved

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Johansson, Mattias
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