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Adaptation in CRISPR-Cas Systems
Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). (Charpentier)ORCID iD: 0000-0002-0254-0778
2016 (English)In: Molecular Cell, ISSN 1097-2765, E-ISSN 1097-4164, Vol. 61, no 6, 797-808 p.Article in journal (Refereed) Published
Abstract [en]

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptation. During the past 3 years, significant progress has been made on the genetic requirements and molecular mechanisms of adaptation. Here we review these recent advances, with a focus on the experimental approaches that have been developed, the insights they generated, and a proposed mechanism for self- versus non-self-discrimination during the process of spacer selection. We further describe the regulation of adaptation and the protein players involved in this fascinating process that allows bacteria and archaea to harbor adaptive immunity.

Place, publisher, year, edition, pages
2016. Vol. 61, no 6, 797-808 p.
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-118635DOI: 10.1016/j.molcel.2016.01.030ISI: 000372327100004PubMedID: 26949040OAI: oai:DiVA.org:umu-118635DiVA: diva2:914864
Available from: 2016-03-27 Created: 2016-03-27 Last updated: 2016-06-02Bibliographically approved

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Charpentier, Emmanuelle
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Department of Molecular Biology (Faculty of Medicine)Molecular Infection Medicine Sweden (MIMS)
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