Change search
ReferencesLink to record
Permanent link

Direct link
Prenatal characteristics of infants with a neuronal migration disorder: a national-based study
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics. Department of Women's and Children's Health, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden; Department of Paediatrics, Östersund County Hospital, Östersund, Sweden.
2012 (English)In: International Journal of Pediatrics, ISSN 1687-9740, E-ISSN 1687-9759, 1-5 p., 541892Article in journal (Refereed) Published
Abstract [en]

The development of the central nervous system is complex and includes dorsal and ventral induction, neuronal proliferation, and neuronal migration, organization, and myelination. Migration occurs in humans in early fetal life. Pathogenesis of malformations of the central nervous system includes both genetic and environmental factors. Few epidemiological studies have addressed the impact of prenatal exposures. All infants born alive and included in the Swedish Medical Birth Register 1980-1999 were included in the study. By linkage to the Patient Register, 820 children with a diagnosis related to a neuronal migration abnormality were identified. Through copies of referrals for computer tomography or magnetic resonance imaging of the brain, the diagnosis was confirmed in 17 children. Median age of the mothers was 29 years. At the start of pregnancy, four out of 17 women smoked. Almost half of the women had a body mass index that is low or in the lower range of average. All infants were born at term with normal birth weights. Thirteen infants had one or more concomitant diseases or malformations. Two infants were born with rubella syndrome. The impact of low maternal body mass index and congenital infections on neuronal migration disorders in infants should be addressed in future studies.

Place, publisher, year, edition, pages
2012. 1-5 p., 541892
Keyword [en]
formula-feeding, human milk, infant nutrition
National Category
URN: urn:nbn:se:umu:diva-118653DOI: 10.1155/2012/541892PubMedID: 22548087OAI: diva2:915035
Available from: 2016-03-29 Created: 2016-03-29 Last updated: 2016-06-29Bibliographically approved

Open Access in DiVA

fulltext(1295 kB)12 downloads
File information
File name FULLTEXT01.pdfFile size 1295 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Naumburg, Estelle
By organisation
In the same journal
International Journal of Pediatrics

Search outside of DiVA

GoogleGoogle Scholar
Total: 12 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 8 hits
ReferencesLink to record
Permanent link

Direct link