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Two Cases of LQT Syndrome with Malignant Syncope after Switch from Propranolol to Bisoprolol
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine.
2016 (English)In: Pacing and Clinical Electrophysiology, ISSN 0147-8389, E-ISSN 1540-8159, Vol. 39, no 3, 305-306 p.Article in journal (Refereed) Published
Abstract [en]

Propranolol in slow-release form has been the first-line treatment in long QT (LQT) until it was withdrawn from the market. We describe two cases where a switch to bisoprolol resulted in worsening of arrhythmia control: A man with LQT2, asymptomatic on propranolol, experienced syncope after switching to bisoprolol 5 mg daily. He switched back to propranolol and has remained asymptomatic during subsequent 12 months. A man with classical Jervell Lange-Nielsen syndrome, previous gangliectomy, and ICD implantation, switched to bisoprolol 5 mg daily. Four months later he experienced a tachycardia storm. He switched back to propranolol and has remained free from arrhythmias during subsequent 12 months.

Place, publisher, year, edition, pages
2016. Vol. 39, no 3, 305-306 p.
Keyword [en]
long QT, pharmacology, beta-blocker therapy, bisoprolol, propranolol
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-118661DOI: 10.1111/pace.12783ISI: 000372408200015PubMedID: 26548443OAI: oai:DiVA.org:umu-118661DiVA: diva2:915042
Available from: 2016-03-29 Created: 2016-03-29 Last updated: 2016-04-25Bibliographically approved

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Kesek, MilosRydberg, AnnikaJensen, Steen M
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