umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Solution structure of the calmodulin-like C-terminal domain of Entamoeba α-actinin2
Swedish NMR Centre at the University of Gothenburg.
Swedish NMR Centre at the University of Gothenburg.
Swedish NMR Centre at the University of Gothenburg.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Show others and affiliations
2016 (English)In: Proteins: Structure, Function, and Genetics, ISSN 0887-3585, E-ISSN 1097-0134, Vol. 84, no 4, 461-466 p.Article in journal (Refereed) Published
Abstract [en]

Cell motility is dependent on a dynamic meshwork of actin filaments that is remodelled continuously. A large number of associated proteins that are severs, cross-links, or caps the filament ends have been identified and the actin cross-linker α-actinin has been implied in several important cellular processes. In Entamoeba histolytica, the etiological agent of human amoebiasis, α-actinin is believed to be required for infection. To better understand the role of α-actinin in the infectious process we have determined the solution structure of the C-terminal calmodulin-like domain using NMR. The final stru-ture ensemble of the apo form shows two lobes, that both resemble other pairs of calcium-binding EF-hand motifs, connected with a mobile linker.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016. Vol. 84, no 4, 461-466 p.
Keyword [en]
a-actinin, structure, Entamoeba
National Category
Structural Biology
Research subject
Biochemistry; biological chemistry
Identifiers
URN: urn:nbn:se:umu:diva-118703DOI: 10.1002/prot.24992ISI: 000373352700005PubMedID: 26800385OAI: oai:DiVA.org:umu-118703DiVA: diva2:915275
Funder
Carl Tryggers foundation
Available from: 2016-03-29 Created: 2016-03-29 Last updated: 2016-05-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hedenström, MattiasBackman, Lars
By organisation
Department of Chemistry
In the same journal
Proteins: Structure, Function, and Genetics
Structural Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 65 hits
ReferencesLink to record
Permanent link

Direct link