Change search
ReferencesLink to record
Permanent link

Direct link
Mutational robustness of ribosomal protein genes.
2010 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 330, no 6005Article in journal (Refereed) Published
Abstract [en]

The distribution of fitness effects (DFE) of mutations is of fundamental importance for understanding evolutionary dynamics and complex diseases and for conserving threatened species. DFEs estimated from DNA sequences have rarely been subject to direct experimental tests. We used a bacterial system in which the fitness effects of a large number of defined single mutations in two ribosomal proteins were measured with high sensitivity. The obtained DFE appears to be unimodal, where most mutations (120 out of 126) are weakly deleterious and the remaining ones are potentially neutral. The DFEs for synonymous and nonsynonymous substitutions are similar, suggesting that in some genes, strong fitness constraints are present at the level of the messenger RNA.

Place, publisher, year, edition, pages
2010. Vol. 330, no 6005
National Category
Microbiology Evolutionary Biology
URN: urn:nbn:se:umu:diva-118567DOI: 10.1126/science.1194617PubMedID: 21051637OAI: diva2:915967
Available from: 2016-03-31 Created: 2016-03-23 Last updated: 2016-03-31

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
MicrobiologyEvolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 6 hits
ReferencesLink to record
Permanent link

Direct link