umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Show others and affiliations
2007 (English)In: The journals of gerontology. Series B, Psychological sciences and social sciences, ISSN 1079-5014, E-ISSN 1758-5368, Vol. 62, no 2, P112-P118 p.Article in journal (Refereed) PublishedText
Abstract [en]

We used data from the Betula Study to examine associations between total cholesterol, triglycerides, and apolipoprotein E on 10-year changes in cognitive performance. Tests assessing episodic memory (recall and recognition), semantic memory (knowledge and fluency), and visuospatial ability (block design) were administered to 524 nondemented adults (initial age of 55-80 years); multilevel modeling was applied to the data. Higher triglyceride levels were associated with a decline in verbal knowledge. Lipid levels moderated the influence of apolipoprotein E on episodic memory, such that among epsilon 4 allele carriers, decline in recognition was noted for individuals with higher cholesterol levels. Cholesterol and triglyceride levels are pharmacologically modifiable risk factors that account for variation In normal cognitive aging.

Place, publisher, year, edition, pages
Washington: The gerontological society of America , 2007. Vol. 62, no 2, P112-P118 p.
Keyword [en]
vascular risk-factors, E epsilon-4 allele, alzheimers disease, cognitive decline, apoe genotype, serum-cholesterol, declarative memory, prospective cohort, blood-pressure, population
National Category
Geriatrics Psychiatry Gerontology, specializing in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-118215ISI: 000253835700007PubMedID: 17379671OAI: oai:DiVA.org:umu-118215DiVA: diva2:918371
Available from: 2016-04-11 Created: 2016-03-14 Last updated: 2016-04-11Bibliographically approved

Open Access in DiVA

No full text

PubMed

Search in DiVA

By author/editor
Adolfsson, RolfCruts, Marc
By organisation
Psychiatry
In the same journal
The journals of gerontology. Series B, Psychological sciences and social sciences
GeriatricsPsychiatryGerontology, specializing in Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 5 hits
ReferencesLink to record
Permanent link

Direct link