Change search
ReferencesLink to record
Permanent link

Direct link
Prognostic and predictive markers in pancreatic adenocarcinoma
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences.
2016 (English)In: Digestive and Liver Disease, ISSN 1590-8658, E-ISSN 1878-3562, Vol. 48, no 3, 223-230 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Pancreatic ductal adenocarcinoma is characterized by a poor prognosis and a low median survival, despite improvements observed for many other solid tumours. Intensive research efforts have been undertaken during the last decades to discover new prognostic and treatment predictive biomarkers for pancreatic ductal adenocarcinoma. The mainstay of medical treatment for the disease has been the well-tolerated nucleoside analogue, gemcitabine. The only targeted agent currently used in pancreatic ductal adenocarcinoma patients is the epithelial growth factor receptor inhibitor erlotinib in combination with gemcitabine. Recently, treatment regimens such as a combination of fluorouracilleucovorin-irinotecan-oxaliplatin (FOLFIRINOX) and the combination of nab-paclitaxel with gemcitabine have been introduced for metastatic pancreatic ductal adenocarcinoma. Although these treatment regimens significantly improve survival of patients, there are no good predictive biomarkers available that can be used to identify who would benefit most from them. Therefore, the search for predictive biomarkers that would facilitate personalization of chemotherapy is highly relevant.

Place, publisher, year, edition, pages
2016. Vol. 48, no 3, 223-230 p.
Keyword [en]
Chemotherapy, Metastatic pancreatic cancer, Predictive marker, Prognostic marker
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-117805DOI: 10.1016/j.dld.2015.11.001ISI: 000369840400002OAI: diva2:918426
Available from: 2016-04-11 Created: 2016-03-04 Last updated: 2016-04-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sund, Malin
By organisation
Department of Surgical and Perioperative Sciences
In the same journal
Digestive and Liver Disease
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link