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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
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2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, 10495Article in journal (Refereed) Published
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Abstract [en]

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Place, publisher, year, edition, pages
2016. Vol. 7, 10495
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Public Health, Global Health, Social Medicine and Epidemiology
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URN: urn:nbn:se:umu:diva-118411DOI: 10.1038/ncomms10495ISI: 000371012200002PubMedID: 26833246OAI: oai:DiVA.org:umu-118411DiVA: diva2:918534
Available from: 2016-04-11 Created: 2016-03-18 Last updated: 2017-11-30Bibliographically approved

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Shungin, Dmitry

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CiteExportLink to record
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  • apa
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