Change search
ReferencesLink to record
Permanent link

Direct link
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Show others and affiliations
2016 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 7, 10495Article in journal (Refereed) PublishedText
Abstract [en]

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Place, publisher, year, edition, pages
2016. Vol. 7, 10495
National Category
Public Health, Global Health, Social Medicine and Epidemiology
URN: urn:nbn:se:umu:diva-118411DOI: 10.1038/ncomms10495ISI: 000371012200002PubMedID: 26833246OAI: diva2:918534
Available from: 2016-04-11 Created: 2016-03-18 Last updated: 2016-04-11Bibliographically approved

Open Access in DiVA

fulltext(2043 kB)29 downloads
File information
File name FULLTEXT01.pdfFile size 2043 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Shungin, Dmitry
By organisation
MedicineDepartment of Odontology
In the same journal
Nature Communications
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 29 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 35 hits
ReferencesLink to record
Permanent link

Direct link