umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Estimation of benchmark dose for pancreatic damage in cadmium-exposed smelters
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Environmental Medicine.ORCID iD: 0000-0002-5315-1633
Show others and affiliations
2007 (English)In: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 97, no 1, 189-195 p.Article in journal (Refereed) PublishedText
Abstract [en]

The aim of this study was to estimate the benchmark dose (BMD) for pancreas dysfunction caused by cadmium (Cd) exposure in smelters. Smelter workers who had been exposed to Cd for more than 1 year and matching nonoccupationally exposed subjects were asked to participate in this study. Urinary cadmium (UCd) was used as a biomarker for exposure, serum insulin and amylase were used as biomarkers for pancreatic effects. In this study, serum insulin and amylase were lower in the smelter workers than in the nonoccupationally exposed subjects. A significant dose-response relationship with UCd was displayed. BMI)s in terms of urinary Cd corrected for creatinine were calculated by use of BMDS (version 1.3.2). The benchmark dose lower limit of a one-sided 95% confidence interval (BMDL) for 10% excess risk was also determined. It was found that the BMDL10 for serum insulin and serum amylase was 3.7 and 5.3 mu g/g Cr, respectively. Compared to the BMDL for renal damage caused by Cd exposure, identified by the effect biomarkers urinary beta(2)-microglobulin, urinary N-acetyl-beta-glucosaminidase, and urinary albumin (UALB), it was shown that BMDL10 for serum insulin is the lowest among all values and UALB gave the highest value (5.8 mu g/g Cr). This study indicates that Cd exposure can result in pancreatic dysfunction and the effect appears at lower urinary Cd level than renal dysfunction. The endocrine function of the pancreas was affected at lower urinary levels of Cd, compared to the exocrine function, which was seen at higher urinary levels of Cd than those giving rise to renal tubular dysfunction.

Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2007. Vol. 97, no 1, 189-195 p.
Keyword [en]
cadmium exposure, benchmark dose, pancreas, biomarker, renal, endocrine
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-118208DOI: 10.1093/toxsci/kfm016ISI: 000246886500020PubMedID: 17303580OAI: oai:DiVA.org:umu-118208DiVA: diva2:918631
Available from: 2016-04-11 Created: 2016-03-14 Last updated: 2016-04-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Nordberg, Monica
By organisation
Environmental Medicine
In the same journal
Toxicological Sciences
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 6 hits
ReferencesLink to record
Permanent link

Direct link