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Working Memory: Maintenance, Updating, and the Realization of Intentions
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
2016 (English)In: Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, E-ISSN 1943-0264, Vol. 8, no 2, a021816Article in journal (Refereed) PublishedText
Abstract [en]

"Working memory" refers to avast set of mnemonic processes and associated brain networks, relates to basic intellectual abilities, and underlies many real-world functions. Working-memory maintenance involves frontoparietal regions and distributed representational areas, and can be based on persistent activity in reentrant loops, synchronous oscillations, or changes in synaptic strength. Manipulation of content of working memory depends on the dorsofrontal cortex, and updating is realized by a frontostriatal '"gating" function. Goals and intentions are represented as cognitive and motivational contexts in the rostrofrontal cortex. Different working-memory networks are linked via associative reinforcement-learning mechanisms into a self-organizing system. Normal capacity variation, as well as working-memory deficits, can largely be accounted for by the effectiveness and integrity of the basal ganglia and dopaminergic neurotransmission.

Place, publisher, year, edition, pages
2016. Vol. 8, no 2, a021816
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-118399DOI: 10.1101/cshperspect.a021816ISI: 000371181300006OAI: oai:DiVA.org:umu-118399DiVA: diva2:919143
Available from: 2016-04-13 Created: 2016-03-18 Last updated: 2016-04-13Bibliographically approved

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Nyberg, LarsEriksson, Johan
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Umeå Centre for Functional Brain Imaging (UFBI)
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ReferencesLink to record
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