umu.sePublications
Change search
ReferencesLink to record
Permanent link

Direct link
Structural Bioinformatics in Broad-Spectrum Racemases: a new path in anti-microbial research
Department of Crystallography and Structural Biology, Instituto de Química Física "Rocasolano", CSIC, Madrid, Spain.
Univ Alcala De Henares, Area Farmacol, Dept Ciencias Biomed, Unidad Asociada I D I,CSIC, Madrid, Spain.
Univ Alcala De Henares, Area Farmacol, Dept Ciencias Biomed, Unidad Asociada I D I,CSIC, Madrid, Spain.
Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
Show others and affiliations
2016 (English)In: Current organic chemistry, ISSN 1385-2728, E-ISSN 1875-5348, Vol. 20, no 11, 1222-1231 p.Article in journal (Refereed) PublishedText
Abstract [en]

D-amino acids are essential components of the bacterial cell wall and play notable roles in microbiology as regulators, for example in sporulation, biofilm formation or interspecies communication. Racemases are the specific enzymes catalyzing the interconversion of L-amino acids to D-amino acids. While most of racemases are mono-specific, a family of broad-spectrum racemases that can racemize ten of the 19 natural chiral amino acids has been recently reported. These enzymes can interconvert radically different residues such as aliphatic and positively charged residues producing non-canonical D-amino acids. Crystal structures together with bioinformatics allowed identification of the residues defining the molecular footprint in broad-spectrum racemases, the specific features of their active sites and the structural basis of their promiscuity. Here we review the recent knowledge on this family compared with the well established of alanine racemases. This structural information is a prerequisite for the development of novel drugs against the important human pathogens for which broad-spectrum racemases play a key role.

Place, publisher, year, edition, pages
Bentham Science , 2016. Vol. 20, no 11, 1222-1231 p.
Keyword [en]
Non-canonical D-amino acids, racemases, bioinformatics, antibiotics resistance, X-ray crystallography
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-119090DOI: 10.2174/1385272819666150810213115ISI: 000372074800006OAI: oai:DiVA.org:umu-119090DiVA: diva2:919174
Available from: 2016-04-13 Created: 2016-04-11 Last updated: 2016-04-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Cava, Felipe
By organisation
Molecular Infection Medicine Sweden (MIMS)Umeå Centre for Microbial Research (UCMR)
In the same journal
Current organic chemistry
Microbiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link