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Plasma metabolomic response to postmenopausal weight loss induced by different diets
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin. Norrlands University Hospital, Umeå University, Umeå, Sweden . (Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden)
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
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2016 (Engelska)Ingår i: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 12, nr 5, artikel-id 85Artikel i tidskrift (Refereegranskat) Published
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Abstract [en]

Background Menopause is associated with increased abdominal fat and increased risk of developing diabetes and cardiovascular disease. Objectives The present study evaluated the plasma metabolic response in relation to insulin sensitivity after weight loss via diet intervention. Methods This work includes two studies; i) Ten women on a 5 weeks Paleolithic-type diet (PD, 30 energy percent (E%) protein, 40 E% fat, 30 E% carbohydrates), ii) 55 women on 6 months of either PD or Nordic Nutrition Recommendations diet (NNR, 15 E% protein, 30 E% fat, and 55 E% carbohydrates). Plasma metabolic profiles were acquired at baseline and post diet using gas chromatography time-of-flight/mass spectrometry and investigated in relation to insulin sensitivity using multivariate bioinformatics. Results Both the PD and NNR diet resulted in significant weight loss, reduced waist circumference, improved serum lipid profiles, and improved insulin sensitivity. We detected a baseline metabolic profile that correlated significantly with insulin sensitivity, and of which components increased significantly in the PD group compared to NNR. Specifically, a significant increase in myo-inositol (MI), a second messenger of insulin action, and beta-hydroxybutyric acid (beta-HB)increased while dihomogamma-linoleic acid (DGLA) decreased in PD compared to NNR, which correlated with improved insulin sensitivity. We also detected a significant decrease in tyrosine and tryptophan, potential markers of insulin resistance when elevated in the circulation, with the PD but not the NNR. Conclusions Using metabolomics, we detected changes in the plasma metabolite profiles associated with weight loss in postmenopausal women by different diets. The metabolic profiles following 6 months of PD were linked to beneficial effects on insulin sensitivity compared to NNR.

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Springer, 2016. Vol. 12, nr 5, artikel-id 85
Nyckelord [en]
Metabolomics, Mass spectrometry, Multivariate analysis, Paleolithic-type diet (PD), Nordic Nutrition commendation (NNR), Type 2 diabetes mellitus (T2DM), Insulin sensitivity, Weight loss, Myoinositol I), 1, 5-anhydroglucitol (1, 5-AG)
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URN: urn:nbn:se:umu:diva-119058DOI: 10.1007/s11306-016-1013-xISI: 000372157700008OAI: oai:DiVA.org:umu-119058DiVA, id: diva2:921447
Tillgänglig från: 2016-04-20 Skapad: 2016-04-11 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Chorell, ElinRyberg, MatsSandberg, SusanneMellberg, CarolineLindahl, BerntAntti, HenrikOlsson, Tommy

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