Change search
ReferencesLink to record
Permanent link

Direct link
ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
Show others and affiliations
2015 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 4, e08428Article in journal (Refereed) PublishedText
Abstract [en]

Brown adipose tissue (BAT) activation via cold exposure is increasingly scrutinized as a potential approach to ameliorate cardio-metabolic risk. Transition to cold temperatures requires changes in the partitioning of energy substrates, re-routing fatty acids to BAT to fuel non-shivering thermogenesis. However, the mechanisms behind the redistribution of energy substrates to BAT remain largely unknown. Angiopoietin-like 4 (ANGPTL4), a protein that inhibits lipoprotein lipase (LPL) activity, is highly expressed in BAT. Here, we demonstrate that ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to BAT during cold. Specifically, we show that cold markedly down-regulates ANGPTL4 in BAT, likely via activation of AMPK, enhancing LPL activity and uptake of plasma triglyceride-derived fatty acids. In contrast, cold up-regulates ANGPTL4 in WAT, abolishing a cold-induced increase in LPL activity. Together, our data indicate that ANGPTL4 is an important regulator of plasma lipid partitioning during sustained cold.

Place, publisher, year, edition, pages
eLife Sciences Publications , 2015. Vol. 4, e08428
National Category
Microbiology in the medical area
URN: urn:nbn:se:umu:diva-119687DOI: 10.7554/eLife.08428ISI: 000373443000001OAI: diva2:922869
Available from: 2016-04-25 Created: 2016-04-25 Last updated: 2016-04-25Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Physiological chemistry
In the same journal
Microbiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 7 hits
ReferencesLink to record
Permanent link

Direct link