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The potential biochemical markers of Kashin-Beck disease. A meta-analysis.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). School of Public Health, Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Xi'an, People's Republic of China. (Chondrogenic and Osteogenic Differentiation Group)ORCID iD: 0000-0002-6181-9904
2016 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, 27097773Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVE: The objective of this study is to explore the cytokines in serum, synovial fluid as potential biomarkers of Kashin-Beck disease (KBD) and to further understand the role of these cytokines in the pathogenesis of KBD.

METHODS: A systematic electronic database search was performed from inception up to 15 March 2015. Meta-analysis was performed for cytokines more than one repetition in studies with available data. The effect size was summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) by a random effect model.

RESULTS: A total of 18 articles were included. The pooled standardized mean differences showed the serum levels of tumor necrosis factor alpha (2.72, 95% CI: 1.8 5-3.59), interleukin-1 beta (1.21, 95% CI: 0.6 1-1.80), and nitric oxide (2.60, 95% CI: 1.5 2-3.68) were significantly higher in adult KBD patients compared with that in healthy controls.

CONCLUSIONS: There was explicit evidence showing that the tumor necrosis factor alpha, interleukin-1 beta and nitric oxide were closely related to the presence of KBD, and these cytokines played a vital role in the pathogenesis of KBD.

Place, publisher, year, edition, pages
Taylor & Francis, 2016. 27097773
Keyword [en]
Biomarkers, cytokines, Kashin-Beck disease, meta-analysis
National Category
Rheumatology and Autoimmunity Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Public health
Identifiers
URN: urn:nbn:se:umu:diva-119781DOI: 10.3109/1354750X.2016.1171905PubMedID: 27097773OAI: oai:DiVA.org:umu-119781DiVA: diva2:923642
Available from: 2016-04-27 Created: 2016-04-27 Last updated: 2016-08-24

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Lammi, Mikko Juhani
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