Cationic contrast agent diffusion differs between cartilage and meniscus.
2016 (English)In: Annals of Biomedical Engineering, ISSN 0090-6964, E-ISSN 1573-9686, 27129372Article in journal (Refereed) Epub ahead of print
Contrast enhanced computed tomography (CECT) is a non-destructive imaging technique used for the assessment of composition and structure of articular cartilage and meniscus. Due to structural and compositional differences between these tissues, diffusion and distribution of contrast agents may differ in cartilage and meniscus. The aim of this study is to determine the diffusion kinematics of a novel iodine based cationic contrast agent (CA(2+)) in cartilage and meniscus. Cylindrical cartilage and meniscus samples (d = 6 mm, h ≈ 2 mm) were harvested from healthy bovine knee joints (n = 10), immersed in isotonic cationic contrast agent (20 mgI/mL), and imaged using a micro-CT scanner at 26 time points up to 48 h. Subsequently, normalized X-ray attenuation and contrast agent diffusion flux, as well as water, collagen and proteoglycan (PG) contents in the tissues were determined. The contrast agent distributions within cartilage and meniscus were different. In addition, the normalized attenuation and diffusion flux were higher (p < 0.05) in cartilage. Based on these results, diffusion kinematics vary between cartilage and meniscus. These tissue specific variations can affect the interpretation of CECT images and should be considered when cartilage and meniscus are assessed simultaneously.
Place, publisher, year, edition, pages
Springer, 2016. 27129372
Computed tomography, contrast enhancement, diffusion flux, diffusion kinematics, normalized attenuation, cartilage, meniscus
Orthopedics Other Basic Medicine Radiology, Nuclear Medicine and Medical Imaging
Research subject Diagnostic Radiology; Orthopaedics; Radiology
IdentifiersURN: urn:nbn:se:umu:diva-119970DOI: 10.1007/s10439-016-1629-zPubMedID: 27129372OAI: oai:DiVA.org:umu-119970DiVA: diva2:925878