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Non-Steroidal Anti-Inflammatory Drug Use and Risk of Anastomotic Leakage after Anterior Resection: A Protocol-Based Study
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
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2016 (Engelska)Ingår i: Digestive Surgery, ISSN 0253-4886, E-ISSN 1421-9883, Vol. 33, nr 2, s. 129-135Artikel i tidskrift (Refereegranskat) Published
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Abstract [en]

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) have been introduced as opioid-sparing analgesics in colorectal surgery. However, recent research has implicated these drugs as risk factors for anastomotic dehiscence.

Methods: The Swedish Colorectal Cancer Registry was used to identify all patients operated with anterior resection for rectal cancer at centres that performed more than 25 abdominal operations per year, from 2007 to 2012, inclusive. The registry provided individual patient data on demographic variables and symptomatic anastomotic leakage. The patient exposure to NSAIDs was defined according to the protocol of the hospital at which the patient was operated. Logistic regression was employed to estimate ORs and 95% CIs, adjusting for confounders.

Results: The study cohort comprised 2,605 patients operated at 21 centres. In the NSAID group, 102/1,458 (7.0%) suffered an anastomotic leak, as compared to 124/1,023 (10.8%) in the non-NSAID group. With adjustment for confounding, patients treated at NSAID hospitals had a reduced risk of developing anastomotic leakage (OR 0.68; 95% CI 0.48-0.96).

Conclusions: In this retrospective protocol-based study, NSAIDs did not increase the risk of anastomotic leakage after anterior resection for rectal cancer. The postoperative use of NSAIDs may not be detrimental, but more research is warranted.

Ort, förlag, år, upplaga, sidor
2016. Vol. 33, nr 2, s. 129-135
Nyckelord [en]
Non-steroidal anti-inflammatory drug, Rectal cancer, Dehiscence
Nationell ämneskategori
Kirurgi Gastroenterologi
Identifikatorer
URN: urn:nbn:se:umu:diva-118994DOI: 10.1159/000443216ISI: 000371788100007OAI: oai:DiVA.org:umu-118994DiVA, id: diva2:925897
Tillgänglig från: 2016-05-03 Skapad: 2016-04-07 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Rutegård, MartinHaapamäki, MarkkuRutegård, Jörgen

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