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Cerebrospinal fluid concentration of Galectin-9 is increased in secondary progressive multiple sclerosis
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
2016 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 292, 40-44 p.Article in journal (Refereed) PublishedText
Abstract [en]

Galectin-9 is produced by activated astrocytes, induces a pro -inflammatory response in microglia and maybe important to the pathogenesis of secondary progressive MS. In this study, Galectin-9 concentrations in CSF samples from healthy controls and two independent patient cohorts of MS patients were determined by ELISA. Patients from one of the cohorts underwent MRI as well. Galectin-9 concentrations in CSF were higher in SPMS patients than healthy controls and RRMS patients in both cohorts. Galectin-9 concentrations correlated with the number of lesions on Tl-weighted images, but not with gadolinium enhancing lesions, IgG index or CSF cell count.

Place, publisher, year, edition, pages
2016. Vol. 292, 40-44 p.
Keyword [en]
Biomarker, CSF, Multiple sclerosis, Galectin-9
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-119286DOI: 10.1016/j.jneuroim.2016.01.008ISI: 000372561600006PubMedID: 26943957OAI: oai:DiVA.org:umu-119286DiVA: diva2:928670
Available from: 2016-05-16 Created: 2016-04-15 Last updated: 2016-05-16Bibliographically approved

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Svenningsson, Anders
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Department of Pharmacology and Clinical Neuroscience
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ReferencesLink to record
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