Change search
ReferencesLink to record
Permanent link

Direct link
Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants
Show others and affiliations
2006 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 43, no 5, 673-679 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objective: Certain milk factors may promote the growth of a host-friendly gastrointestinal microbiota, for example, one that is predominated by bifidobacteria, a perceived healthpromoting genus. This may explain why breast-fed infants experience fewer intestinal infections than their formula-fed counterparts who are believed to have a more diverse microbiota, which is similar to that of adults. The effects of formulas supplemented with 2 such ingredients from bovine milk, a-lactalbumin (alpha-lac) and casein glycomacropeptide (GMP), on gut flora were investigated in this study.

Patients and Methods: Six-week-old (4-8 wk), healthy term infants were randomised to a standard infant formula or 1 of 2 test formulae enriched in alpha-Jac with higher or lower GMP until 6 months. Faecal bacteriology was determined by the culture-independent procedure fluorescence in situ hybridisation.

Results: There was a large fluctuation of bacterial counts within groups with no statistically significant differences between groups. Although all groups showed a. predominance of bifidobacteria, breast-fed infants had a small temporary increase in counts. Other bacterial levels varied in formula-fed groups, which overall showed an adult-like faecal microflora.

Conclusions: It can be speculated that a prebiotic effect for alpha-lac and GMP is achieved only with low starting populations of beneficial microbiota (eg, infants not initially breast-fed).

Place, publisher, year, edition, pages
Philadelphia: Lippincott Williams & Wilkins, 2006. Vol. 43, no 5, 673-679 p.
Keyword [en]
infant nutrition, casein glycomacropeptide, alpha-lactalbumin, fluorescence in situ hybridization, human trials
National Category
Pediatrics Nutrition and Dietetics Gastroenterology and Hepatology
URN: urn:nbn:se:umu:diva-119374DOI: 10.1097/01.mpg.0000232019.79025.8fISI: 000241906800022PubMedID: 17130747OAI: diva2:928709
Available from: 2016-05-16 Created: 2016-04-18 Last updated: 2016-05-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Bruck, Wolfram MTuohy, Kieran MHernell, Olle
By organisation
In the same journal
Journal of Pediatric Gastroenterology and Nutrition - JPGN
PediatricsNutrition and DieteticsGastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 7 hits
ReferencesLink to record
Permanent link

Direct link