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Higher diurnal salivary cortisol levels are related to smaller prefrontal cortex surface area in elderly men and women
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine. Region Jönköping County, Jönköping, Sweden.
Umeå University, Faculty of Social Sciences, Centre for Demographic and Ageing Research (CEDAR). Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).ORCID iD: 0000-0002-4458-6475
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2016 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 175, no 2, 117-126 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Elevated cortisol levels with aging have been associated with atrophy of the hippocampus and prefrontal cortex (PFC), as well as with impaired cognitive functions in men. However, coexisting diseases have confounded many studies examining these relationships. Studies in women are lacking. Our objective was to test whether salivary cortisol levels were related to morphology of the hippocampus and the PFC, and to cognitive performance. Design: A cross-sectional study including 200 elderly (55-80 years old) men and women. Method: We used magnetic resonance imaging, tests of episodic-, semantic-, and working memory, visuospatial ability, and cortisol levels in four saliva samples collected during 1 day. Results: Area under the curve (AUC) for cortisol levels was negatively related to cortical surface area of the left anterior cingulate gyrus (caudal P < 0.001; rostral P = 0.006), right lateral orbitofrontal cortex (P = 0.004), and right rostral middle frontal gyrus (P = 0.003). In women, there was also a negative relationship with cortical surface area in the left rostral middle frontal gyrus (P = 0.006). No relationship was found between cortisol levels and hippocampal volume. Conclusion: This study suggests that the structure of the medial PFC is related to cortisol levels in both elderly women and men.

Place, publisher, year, edition, pages
2016. Vol. 175, no 2, 117-126 p.
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-121117DOI: 10.1530/EJE-16-0352ISI: 000380067200010PubMedID: 27190207OAI: oai:DiVA.org:umu-121117DiVA: diva2:931091
Available from: 2016-05-26 Created: 2016-05-26 Last updated: 2016-08-22Bibliographically approved

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Stomby, AndreasBoraxbekk, Carl-JohanLundquist, AndersNordin Adolfsson, AnnelieNilsson, Lars-GöranAdolfsson, RolfNyberg, LarsOlsson, Tommy
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MedicineCentre for Demographic and Ageing Research (CEDAR)Umeå Centre for Functional Brain Imaging (UFBI)PsychiatryPhysiologyDiagnostic Radiology
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European Journal of Endocrinology
Endocrinology and Diabetes

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